After the DATS group leaves the Gorge of Deception, Yoshi is found to be sick. Having no choice, the DATS team stops inside a cave to take care of Yoshi. Keenan and Falcomon come to the cave to stop the humans and Keenan contracts the same disease from Yoshi. Falcomon is forced to help DATS find the vaccine needed to cure the disease, much to the annoyance of Gotsumon who labels Falcomon a traitor. The group of Marcus, Agumon, Thomas, Gaomon and Falcomon arrive at Wanderer's Cape, where there is an upside-down mansion that was inhabited by humans on their first journey to the Digital World. There they encounter Blossomon, sent by Gotsumon to dispatch the humans. Falcomon takes off with the vaccine after he promises to give it to both Yoshi and Keenan, leaving RizeGreymon and MachGaogamon to deal with Blossomon. When she is finally destroyed, Marcus and Thomas go back to the cave Yoshi is to find out that Falcomon gave Yoshi the vaccine as he promised.
(Numbers indicate order of appearance. Bolded characters are fought by the protagonists, and italicized characters appear only as a voice or silhouette.)
Gaomon: "Miss Yoshino is a woman. It's natural for her to want her privacy." Marcus: "Thomas is a guy and he's in there!" Agumon: "Don't stop so quick, boss!" Gaomon: "Master Norstein happens to have a medical license." Marcus: "Medical license! How does he have that when he's the same age as me?" Gaomon: "He's smarter than you."